diskhoogl.blogg.se

Male mice knockouts oxytocin social amnesia
Male mice knockouts oxytocin social amnesia










Received: AugAccepted: DecemPublished: December 30, 2015Ĭopyright: © 2015 Zhang et al. PLoS ONE 10(12):Įditor: Barbara Bardoni, CNRS UMR7275, FRANCE (2015) The Effect of Oxytocin on Social and Non-Social Behaviour and Striatal Protein Expression in C57BL/6N Mice. Our results here encourage further research into the clinical application of this peptide hormone, which may potentially extend treatment options across a spectrum of neurodevelopmental conditions.Ĭitation: Zhang X, Li Q, Zhang M, Lam S, Sham PC, Bu B, et al. The proteins affected by oxytocin could be broadly categorized as those that modulate glutamatergic, GABAergic or dopaminergic signalling and those that mediate cytoskeleton dynamics. With the caveat that these results are preliminary, oxytocin appeared to alter individual protein expression in directions similar to conventional anti-psychotics. The striatum proteome following oxytocin exposure could be clearly discriminated from saline controls. It increased social interaction time and suppressed the amphetamine locomotor response in both sexes. Oxytocin increased prepulse inhibition of startle but attenuated the recognition memory in male C57BL/6N mice. As the striatum modulates social and non-social behaviours, and is implicated in neurodevelopmental disorders, we also conducted a pilot exploration of changes in striatal protein expression elicited by oxytocin. Here we investigated the effects of a range of oxytocin doses on social and non-social behaviours in C57BL/6N mice of both sexes. However, important gaps remain in our understanding of its mode of action, in particular, to what extent oxytocin modulates social and non-social behaviours and whether its effects are generalizable across both sexes. Oxytocin has been suggested as a promising new treatment for neurodevelopmental disorders.












Male mice knockouts oxytocin social amnesia